Doctors have raised fresh concerns that drug-resistant forms of malaria may be emerging across Africa.
A key malaria treatment has failed for the first time in Britain to cure four patients who had become infected after travelling to Uganda, Angola and Liberia.
They initially responded well to an anti-malarial therapy (artemether-lumefantrine) but relapsed a month later.
Tests on samples of the parasite that caused their malaria suggest it may be developing resistance to the combination drug.
Doctors say this reflects anecdotal evidence from African countries that treatment is failing on a much larger scale and needs further study.
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